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KMID : 0360220120530010120
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Journal of the Korean Ophthalmological Society
2012 Volume.53 No. 1 p.120 ~ p.126
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Effect of Laser Photocoagulation and Intravitreal Bevacizumab Injection on Zone I Retinopathy of Prematurity
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Choi Won
Heo Hwan
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Abstract
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Purpose: To evaluate the efficacy and safety of laser photocoagulation and intravitreal injection of bevacizumab in zone I ROP (retinopathy of prematurity) accompanied with plus signs.
Methods: We performed a retrospective analysis of the records of 12 eyes of 7 premature infants with zone I ROP accompanied with plus signs, treated with diode laser photocoagulation and intravitreal injection of bevacizumab that were followed-up for at least 12 months.
Results: Mean gestational age was 30 + 2 weeks, mean birth weight was 1437 ± 478 g, mean follow-up period was 14.7 ± 2.0 months and mean age of diagnosis was 36 + 3 weeks. Plus signs were disappeared after an average of 10.1 ± 2.4 postoperative days in all 12 eyes. The outcome was favorable in 11 (91.7%) of 12 treated eyes after a minimum of 12 months of follow-up. No local or systemic complications were observed.
Conclusions: Laser photocoagulation and intravitreal injection of bevacizumab are effective and safe for treatment of zone I ROP accompanied with plus signs and require long-term follow-up.
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KEYWORD
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Bevacizumab, Laser photocoagulation, Retinopathy of prematurity
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